Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (10): 2168-2175.DOI: 10.6023/cjoc201503048 Previous Articles     Next Articles



黄燕敏a, 姚秋翠b, 刘志平a, 甘春芳a, 郑嘉桦a, 盛海兵a, 石海信c, 崔建国a,c   

  1. a 广西师范学院化学与材料科学学院 南宁 530001;
    b 北部湾环境演变与资源利用重点实验室 广西师范学院 南宁 530219;
    c 广西高校北部湾石油天然气资源有效利用重点实验室 钦州学院 钦州 535000
  • 收稿日期:2015-03-29 修回日期:2015-05-23 发布日期:2015-06-19
  • 通讯作者: 崔建国
  • 基金资助:

    国家自然科学基金(No. 21462009)和广西高校北部湾石油天然气资源有效利用重点实验室开放课题(No. 2014KLOG09)资助项目.

Synthesis and Antiproliferative Evaluation of Chenodeoxycholic Acid Containing-Nitrogen Derivatives

Huang Yanmina, Yao Qiucuib, Liu Zhipinga, Gan Chunfanga, Zheng Jiahuaa, Sheng Haibinga, Shi Haishingc, Cui Jianguoa,c   

  1. a Chemistry and Materials Science College, Guangxi Teachers Education University, Nanning 53001;
    b Key Laboratory of Beibu GulfEnvironment Change and Resources Utilization, Guangxi Teachers Education University, Nanning 530219;
    c Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resoure Effective Utilization, Qinzhou University, Qinzhou 535000
  • Received:2015-03-29 Revised:2015-05-23 Published:2015-06-19
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462009, 21562007) and the Opening Project of Guangxi Colleges and Universities Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization (No. 2014KLOG09).

Chenodeoxycholic acid nitrogen-containing derivatives display anti-tumor activities and induce apoptosis of the cacer cells. Some chenodeoxycholic acid derivatives possessing various nitrogen-containing substituent in 3-or 7-position of steroidal nucleus were designed and synthesized using chenodeoxycholic acid as starting materials. Their structures were characterized by IR, NMR and MS. Antiproliferative activities of the compounds were assayed against human gastric cancer cells (SGC-7901), human hepatic cancer (Bel-7404) and prostate cancer cell (PC-3) by MTT method. The results showed that some nitrogen-containing derivatives of chenodeoxycholic acid had better antiproliferative activities against Bel-7404 and PC-3 cells.

Key words: chenodeoxycholic acid, nitrogen-containing compounds, antiproliferative activity, bioactivity