Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2372-2376.DOI: 10.6023/cjoc201504015 Previous Articles     Next Articles



黄海静, 刘巨艳, 马恩忠, 曹映玉   

  1. 天津师范大学化学学院 天津市功能分子结构与性能重点实验室 无机-有机杂化功能材料化学省部共建教育部重点实验室 天津 300387
  • 收稿日期:2015-04-12 修回日期:2015-06-18 发布日期:2015-07-02
  • 通讯作者: 刘巨艳, 马恩忠, 曹映玉
  • 基金资助:

    天津市自然科学基金(No. 12JCZDJC34300)、大学生创业训练项目(No. 201447)、天津师范大学博士基金(No. 52XB1111)资助项目.

A General and Efficient Method for the Formylation of Amines Catalyzed by Bromodimethylsulfonium Bromide

Huang Haijing, Liu Juyan, Ma Enzhong, Cao Yingyu   

  1. Tianjin Key Laboratory of Structure and Performance for Functional Molecule, Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, College of Chemistry, Tianjin Normal University, Tianjin 300387
  • Received:2015-04-12 Revised:2015-06-18 Published:2015-07-02
  • Supported by:

    Project supported by the Natural Science Foundation of Tianjin City (No. 12JCZDJC34300), the College Students' Entrepreneurship Training Program (No. 201447), the Doctoral Fund of Tianjin Normal University (No. 52XB1111).

A fast, efficient and simple route for the N-formylation of amines has been developed by treating amines with 85% formic acid at room temperature in the presence of 5 mol% of bromodimethylsulfonium bromide as catalyst under solvent-free condition. This method provides a green and much improved protocol over the existing methods.

Key words: Amine, N-formylation, bromodimethylsulfonium bromide (BDMS), solvent-free