Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2275-2290.DOI: 10.6023/cjoc201505031 Previous Articles     Next Articles



卢贝丽, 李现艳, 林咏梅   

  1. 福建农林大学材料工程学院 福州 350002
  • 收稿日期:2015-05-19 修回日期:2015-06-29 发布日期:2015-07-10
  • 通讯作者: 卢贝丽
  • 基金资助:

    国家自然科学基金(Nos. 21402027)、福建省自然科学基金(No. 2015J05046)、福建省教育厅A类科技(No. JA14108)资助项目.

Recent Development of Indole Synthesis by Transition Metal Catalyzed C—H Functionalization

Lu Beili, Li Xianyan, Lin Yongmei   

  1. College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002
  • Received:2015-05-19 Revised:2015-06-29 Published:2015-07-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21402027), the Natural Science Foundation of Fujian Province (No. 2015J05046) and the Education Department of Fujian Province (No. JA14108).

Indoles represent important scaffolds in a large family of bioactive molecules and natural products. These compounds display a wide range of unique properties, which have been widely applied to clinical pharmaceuticals, materials and industries. In recent years, transition metal catalyzed C—H bond functionalization for the efficient construction of indole motifs has attracted much attention from chemical society. This review presents the recent development in this area and highlights the different advantages associated with transition metal catalyzed C—H bond functionalizations. The applications of the methodology on the synthesis of natural products and bioactive molecules containing indole skeletons have also been introduced.

Key words: indole, transition metal catalysis, C—H functionalization