Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2366-2371.DOI: 10.6023/cjoc201505034 Previous Articles     Next Articles



马金龙, 翟艳光, 朱俐, 赵育   

  1. 南通大学航海医学研究所 南通 226001
  • 收稿日期:2015-05-23 修回日期:2015-06-25 发布日期:2015-07-08
  • 通讯作者: 赵育
  • 基金资助:

    南通市自然科学基金(No. BK2014069)、江苏省高校优势学科资(PAPD)资助项目.

Synthesis of 1-(1H-Pyrrol-3-yl)-1,2-dihydroisoquinoline Derivatives via AgOTf-Catalyzed One-Pot Reaction

Ma Jinlong, Zhai Yanguang, Zhu Li, Zhao Yu   

  1. Institute of Nautical Medicine, Nantong University, Nantong 226001
  • Received:2015-05-23 Revised:2015-06-25 Published:2015-07-08
  • Supported by:

    Project supported by the Natural Science Foundation of Nantong City (No. BK2014069) and the Priority Academic Program Development of Jiangsu Higher Education Instititutions (PAPD).

Three-component reactions of 2-alkynylbenzaldehydes, amines and pyrrole catalyzed by AgOTf give 1-(1H-pyr- rol-3-yl)-1,2-dihydroisoquinolines in good yields. The chemical structures of these compounds were confirmed by 1H NMR, 13C NMR and HRMS techniques

Key words: 2-alkynylbenzaldehyde, amine, pyrrole, 1,2-dihydroisoquinoline, synthesize