Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2507-2521.DOI: 10.6023/cjoc201505045 Previous Articles     Next Articles



傅颖, 侯博, 赵兴玲, 杜正银, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2015-05-28 修回日期:2015-06-29 发布日期:2015-08-17
  • 通讯作者: 傅颖
  • 基金资助:

    国家自然科学基金(Nos. 21262030, 20962017)和甘肃省自然科学基金(No. 1107RJZA263)资助项目.

Progress on the Asymmetric Silylcyanation of Aldehydes and Ketones

Fu Ying, Hou Bo, Zhao Xingling, Du Zhengyin, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2015-05-28 Revised:2015-06-29 Published:2015-08-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21262030, 20962017) and the Natural Science Foundation of Gansu Province (No. 1107RJZA263).

The asymmetric cyanation of carbonyl compounds occupies a hot research topic in current catalytic chemistry. Optically pure cyanohydrins are important synthetic intermediates which can be easily transformed into optically pure compounds, including β-aminoalcohols, α-amino acids and α-hydroxy acids, thus exihibits fundermental utility in many natural products and chemical pharmacy synthesis. Presently, the asymmetric silylcyanation of trimethylsilyl cyanide with aldehydes and ketones represents a main approach for optically pure cyanohydrin synthesis. The complex of chiral ligand and Lewis acid is the key element that determines the efficiency and controls the stereochemisty of these reactions. This review briefly summarizes the development of asymmetric catalysis empolyed in the chiral cyanohydation of aldehydes and ketones using trimethylsilyl cyanide as the cyanating agent.

Key words: chiral catalysis, asymmetric silylcyanation, aldehyde and ketone, chiral ligand