Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2447-2464.DOI: 10.6023/cjoc201509027 Previous Articles     Next Articles



杜明军a, 雷晓光a,b   

  1. a 天津大学药物科学与技术学院 天津 300072;
    b 北京大学化学与分子工程学院 北京 100871
  • 收稿日期:2015-09-21 修回日期:2015-10-22 发布日期:2015-10-26
  • 通讯作者: 雷晓光

Advanced in the Synthesis of Kaurane Diterpenoids

Du Mingjuna, Lei Xiaoguanga,b   

  1. a Shoool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072;
    b College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  • Received:2015-09-21 Revised:2015-10-22 Published:2015-10-26

Kaurane, especially ent-kaurane diterpenoids are integral parts of terpenoid natural products, and possess various bioactivities, including antibacterial, antitumor, antimalarial and antiviral activities. Additionally, as a result of intramolecular oxidations, cleavages and rearrangements, the tetracyclic ent-kaurane also shows attractive structural diversity. Hence, the total syntheses of ent-kauranes have evoked a great deal of interest in the synthetic community. This review presents the recent advances in the synthesis of ent-kaurane and kauranediterpenoids.

Key words: diterpenoids, ent-kaurane, total synthesis