Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (4): 867-871.DOI: 10.6023/cjoc201511023 Previous Articles     Next Articles



杨太群a,b, 戴山a, 秦翠芳a, 黄科翰a, 陈瑜婷a, 潘海峰a, 张三军a,c, 张坤b, 徐建华a,c   

  1. a. 华东师范大学 精密光谱科学与技术国家重点实验室 上海 200062;
    b. 华东师范大学化学系 上海市绿色化学与化工过程绿色化重点实验室 上海 200062;
    c. 山西大学极端光学协同创新中心 太原 030006
  • 收稿日期:2015-11-13 修回日期:2015-12-03 发布日期:2015-12-10
  • 通讯作者: 张三军
  • 基金资助:


Selective Detection of Homocysteine by Using Poly Methyl Vinyl Ether-alt-Maleic Silver Clusters

Yang Taiquna,b, Dai Shana, Qin Cuifanga, Huang Kehana, Chen Yutinga, Pan Haifenga, Zhang Sanjuna,c, Zhang Kunb, Xu Jianhuaa,c   

  1. a. State Key Laboratory of Precision Spectroscopy, East China. Normal University, Shanghai 200062;
    b. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry East China. Normal University, Shanghai 200062;
    c. Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006
  • Received:2015-11-13 Revised:2015-12-03 Published:2015-12-10
  • Supported by:

    Project supported by the Science and Technology Commission of Shanghai Municipality (No. 15ZR1410100) and the National Natural Science Fundation of China (No. 61178085).

We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.

Key words: homocysteine, poly methyl vinyl ether-alt-maleic acid, fluorescent sensor, silver nanoclusters