Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (9): 1717-1729.DOI: 10.6023/cjoc201403030 Previous Articles     Next Articles


王胜清, 申世立, 张延如, 戴溪, 赵宝祥   

  1. 山东大学化学与化工学院, 济南 250100
  • 收稿日期:2014-03-12 修回日期:2014-04-25 发布日期:2014-05-07
  • 通讯作者: 赵宝祥

Recent Progress in Fluorescent Probes for the Detection of Biothiols

Wang Shengqing, Shen Shili, Zhang Yanru, Dai Xi, Zhao Baoxiang   

  1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2014-03-12 Revised:2014-04-25 Published:2014-05-07

Intracellular thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play crucial roles in maintaining biological systems. In last decade, developing small molecule probes for selective and sensitive detection of thiols under physiological conditions have attracted great interest. Fluorescent and colorimetric sensors are classified into two types of reactions according to their mechanism of reaction with thiols, including the reaction with mercapto group, the reaction with mercapto and amino group. Therefore, in this review we provide a general overview of the selected recent research involving the design and application of biological thiol-selective chemosensors.

Key words: fluorescence, probe, glutathione, homocysteine, cysteine, thiol