Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (3): 447-459.DOI: 10.6023/cjoc201512009 Previous Articles     Next Articles



王志惠a, 张振锋a, 刘燕刚a, 张万斌a,b   

  1. a 上海交通大学药学院 上海 200240;
    b 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2015-12-07 修回日期:2016-01-06 发布日期:2016-01-15
  • 通讯作者: 张振锋, 张万斌
  • 基金资助:

    国家自然科学基金(No. 21572131)和上海市科学技术委员会(No. 14XD1402300)资助项目.

Development of the Asymmetric Hydrogenation of Enol Esters

Wang Zhihuia, Zhang Zhenfenga, Liu Yanganga, Zhang Wanbina,b   

  1. a School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240;
    b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2015-12-07 Revised:2016-01-06 Published:2016-01-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21572131) and the Science and Technology Commission of Shanghai Municipality (No. 14XD1402300).

Chiral alcohols are an important class of compounds and possess a broad array of applications, thus their asymmetric preparation is an important area of research in the field of organic synthesis. Amongst methodologies for the preparation of such compounds, catalytic asymmetric hydrogenation has gained widespread interest due to its efficiency, environmentally friendliness and economic advantages, and is gradually becoming a technology with great potential for the industrial preparation of chiral alcohols. This review provides the first overview for the catalytic asymmetric hydrogenation of enol esters for the synthesis of chiral alcohols. A comprehensive and up-to-date introduction are given for a number of different substrates. A thorough analysis is provided concerning the advantages and disadvantages of different chiral ligands and their transition-metal complexes. Finally, a brief discussion relating to developments and potential areas of further research concerning new substrates, new ligands and new catalytic metals, is presented.

Key words: enol esters, chiral alcohols, asymmetric hydrogenation, Ru-catalyzed, Rh-catalyzed