Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1208-1217.DOI: 10.6023/cjoc201512029 Previous Articles     Next Articles

Reviews

路易斯碱有机小分子催化亚胺的不对称还原研究进展

葛新a,b, 陈新志b, 钱超b   

  1. a 江南大学化学与材料工程学院无锡 214122;
    b 浙江大学生物质化工教育部重点实验室杭州 310027
  • 收稿日期:2015-12-21 修回日期:2016-01-26 出版日期:2016-06-25 发布日期:2016-02-02
  • 通讯作者: 钱超 E-mail:qianchao@zju.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21376213,21476194)、浙江省科技厅公益性技术应用研究计划项目(Nos.2014C31123,2015C31038)、江南大学自主科研计划(No.JUSRP115A05)资助项目.

Progress on the Lewis-Basic Organocatalytic Asymmetric Reduction of Imines

Ge Xina,b, Chen Xinzhib, Qian Chaob   

  1. aSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122;
    b Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027
  • Received:2015-12-21 Revised:2016-01-26 Online:2016-06-25 Published:2016-02-02
  • Supported by:

    Project supported by the Natural Science Foundation of China (Nos. 21376213, 21476194), Zhejiang Provincial Public Technology Research of China (Nos. 2014C31123, 2015C31038) and the Fundamental Research Funds for the Central Universities (No. JUSRP115A05).

Recently, the asymmetric reduction of imines catalyzed by Lewis-basic organocatalyst has been received much attention as the cheap hydrogen source and the simple post treatment. Based on the different functional groups of organocatalysts, this paper introduced formamide, pyridine amide, sulfonamide, supported and other Lewis basic organocatalysts. The structural characteristics, catalytic activity and mechanism of the Lewis-basic organocatalysts were summarized.

Key words: imine, Lewis-base, organocatalyst, asymmetric reduction