Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination

doi:10.6023/cjoc201512040

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1218-1228.DOI: 10.6023/cjoc201512040 Previous Articles Next Articles

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过渡金属催化C—H键氟化反应研究进展 2017-2018 Awarded

何将旗, 娄绍杰, 许丹倩

浙江工业大学催化加氢研究中心浙江省绿色农药清洁生产技术研究重点实验室杭州 310014

收稿日期:2015-12-26 修回日期:2016-01-25 发布日期:2016-02-18
通讯作者: 许丹倩 E-mail:chrc@zjut.edu.cn
基金资助:
国家自然科基金(No.21361130021)、中国博士后面上基金(No.2014M560494)以及浙江省博士后择优资助项目.

Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination

He Jiangqi, Lou Shaojie, Xu Danqian

Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014

Received:2015-12-26 Revised:2016-01-25 Published:2016-02-18
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21361130021), the China Postdoctoral Science Foundation (No. 2014M560494) and the Postdoctoral Science Foundation of Zhejiang Province.

Organofluorine compounds are widely found in pharmaceuticals, agrochemicals, and materials due to their special properties. However, development of transformations to incorporate fluorine atom is usually a great challenge, because of its highly electronegative nature. Transition-metal catalyzed C—H bond fluorination has significant advantages in atom-economy, reaction diversity and environmental friendliness in comparison with the traditional transition-metal catalyzed cross-coupling approaches since it obviates the use of pre-functionalized substrates. In the past decade, C—H bond fluorination strategy has emerged as a powerful protocol to access new C—F bonds. This review presents the state of art for transition-metal catalyzed C—H bond fluorination. The existing problems and limitations of the field are summarized and the outlook of the area is also prospected.

Key words: transition-metal catalysis, fluorination, C—H bond activation, selective, directing groups

Cite this article

He Jiangqi, Lou Shaojie, Xu Danqian. Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination[J]. Chin. J. Org. Chem., 2016, 36(6): 1218-1228.

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过渡金属催化C—H键氟化反应研究进展 2017-2018 Awarded

Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination

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