Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (4): 744-751.DOI: 10.6023/cjoc201512037 Previous Articles     Next Articles



李雪冬, 郎咸东, 宋清文, 郭亚坤, 何良年   

  1. 南开大学元素有机化学国家重点实验室 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2015-12-25 修回日期:2016-01-30 发布日期:2016-02-18
  • 通讯作者: 何良年
  • 基金资助:


Cu(I)-Catalyzed Three-Component Reaction of Propargylic Alcohol, Secondary Amines and Atmospheric CO2

Li Xuedong, Lang Xiandong, Song Qingwen, Guo Yakun, He Liangnian   

  1. State Key Laboratory and Institute of Elemento-Organic. Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071
  • Received:2015-12-25 Revised:2016-01-30 Published:2016-02-18
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. 21472103, 21121002), the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20130031110013) and the National Found for Fostering Talents of Basic Science (No. J1103306).

β-Oxopropylcarbamates constitute an important kind of organic compounds, owing to the extensive applications in agrochemicals, pharmaceuticals, organic synthesis, and protection of amino group. In this article, an efficient and atom-economical Cu(I) catalyzed three-component reaction of propargylic alcohols, secondary amines and CO2 has been developed under atmospheric pressure, affording various β-oxopropylcarbamates in high yields with high selectivity by controlling the concentration of O2. This protocol avoids the use of high pressure of CO2 and provides an extremely simple way to access the synthetically useful β-oxopropylcarbamates.

Key words: CO2, homogeneous catalysis, synthetic methods, Cu, three-component reaction, β-oxopropylcarbamates