Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (11): 2746-2751.DOI: 10.6023/cjoc201605039 Previous Articles     Next Articles



郝二军, 蒋小涵, 付丹丹, 王东超, 谢明胜, 渠桂荣, 郭海明   

  1. 河南师范大学化学化工学院 精细化学品绿色制造河南省协同创新中心 绿色化学介质与反应省部共建教育部重点实验室 新乡 453007
  • 收稿日期:2016-05-22 修回日期:2016-06-28 发布日期:2016-07-15
  • 通讯作者: 王东超
  • 基金资助:


Synthesis of 3-Cyanomethyl Oxoindoles via Palladium-Catalyzed Domino Heck/Cyanation Reaction in Water

Hao Erjun, Jiang Xiaohan, Fu Dandan, Wang Dongchao, Xie Mingsheng, Qu Guirong, Guo Haiming   

  1. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007
  • Received:2016-05-22 Revised:2016-06-28 Published:2016-07-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21472037),the Postdoctoral Science Foundation of Henan Province (No.2015071),and the Innovative Research Team in Science and Technology in University of Henan Province (No.15IRTSTHN003).

3-Cyanomethyl oxoindoles are a kind of important drug intermediates, which can be used to synthesize horsfiline, esermethole and physostigmine and other natural products via the conversion of cyano functional groups. aA domino Heck/cyanation reaction in aqueous was developed to afford 3-cyanomethyl oxoindole compounds. This method, using green medium water instead of organic solvents, without any basic additives, provided a green and efficient new procedure for the synthesis of 3-cyanomethyl oxoindoles.

Key words: cyanation cascade reaction, Heck reaction, 3-cyanomethyl oxoindoles