Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2906-2911.DOI: 10.6023/cjoc201606023 Previous Articles     Next Articles



张锐a, 潘金环a, 吴琼友a   

  1. a 华中师范大学化学学院农药与化学生物学教育部重点实验室 武汉 430079
  • 收稿日期:2016-06-14 修回日期:2016-07-20 发布日期:2016-08-25
  • 通讯作者: 吴琼友
  • 基金资助:

    国家自然科学基金(No. 21272091)、华中师范大学中央高校基本科研业务费(No. CCNU15A02014)资助项目.

Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines

Zhang Ruia, Pan Jinhuana, Wu Qiongyoua   

  1. a Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2016-06-14 Revised:2016-07-20 Published:2016-08-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272091) and the Self-determined Research Funds of Central China Normal University from the Colleges' Basic Research and Operation of Ministry of Education (No. CCNU15A02014).

In this paper, a CuI mediated one-pot muti-component method for the preparation of isoquinoline derivatives under microwave irradiation was developed by using 2-bromobenzaldehyde and terminal alkynes as starting materials, tert-butyl amine as nitrogen source. This methodology provides one convenient and high efficient approach to the 3-substituted isoquinoline library.

Key words: 3-substituted isoquinolines, copper iodide, microwave irradiation, multiple component reaction