Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives

doi:10.6023/cjoc201309014

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2578-2582.DOI: 10.6023/cjoc201309014 Previous Articles Next Articles

Notes

三组分合成噁唑并[3,4-b]喹啉衍生物

佟光进^a,b, 范威^a, 姜波^a

a 江苏师范大学化学化工学院徐州 221116;
b 江苏省徐州医药高等职业学校药学技术系徐州 221116

收稿日期:2013-09-08 修回日期:2013-10-14 发布日期:2013-10-28
通讯作者: 姜波 E-mail:jiangchem@jsnu.edu.cn
基金资助:
国家自然科学青年基金(No. 21102124)和江苏省“青蓝”工程(No. 12QLG006)资助项目.

Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives

Tong Guangjin^a,b, Fan Wei^a, Jiang Bo^a

a School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
b Pharmaceutical Technology, Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Xuzhou 221116

Received:2013-09-08 Revised:2013-10-14 Published:2013-10-28
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21102124) and the Qing Lan Project of Jiangsu Province (No. 12QLG006).

1. Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives.PDF(281KB)

Abstract

A series of oxazolo[3,4-b]quinoline derivatives were regioselectively synthesized by the three component reaction of acridin-1,2-dione derivatives with aldehydes and ammonium acetate in N,N-dimethylformamide (DMF) under microwave irradiation. This method has the advantages of short reaction times (15～18 min), excellent selectivity, and simple operation as well as environmental friendly. The structures of the products were identified by IR, NMR, HRMS, and the crystal of compound 4a was confirmed by X-ray diffraction.

Key words: microwave irradiation, oxazolo[3,4-b]quinoline derivatives, pentacyclic fused heterocycles, three-component reaction

Cite this article

Tong Guangjin, Fan Wei, Jiang Bo. Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives[J]. Chin. J. Org. Chem., 2013, 33(12): 2578-2582.

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三组分合成噁唑并[3,4-b]喹啉衍生物

Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives

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