Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 612-628.DOI: 10.6023/cjoc201709020 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



后际挺a,b, 李坤c, 覃彩芹a,b, 余孝其c   

  1. a 湖北工程学院 生物质资源转化利用湖北省协同创新中心 孝感 432000;
    b 湖北工程学院化学与材料科学学院 孝感 432000;
    c 四川大学化学学院 成都 610064
  • 收稿日期:2017-09-13 修回日期:2017-10-17 发布日期:2017-10-31
  • 通讯作者: 覃彩芹,
  • 基金资助:


Review of the Small Molecular Fluorescent Sensors for Intracellular Reactive Oxygen Species

Hou Jitinga,b, Li Kunc, Qin Caiqina,b, Yu Xiaoqic   

  1. a Hubei Collaboration Innovation Center for Biomass Conversion and Utilization, Hubei Engineering University, Xiaogan 432000;
    b School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000;
    c College of Chemistry, Sichuan University, Chengdu 610064
  • Received:2017-09-13 Revised:2017-10-17 Published:2017-10-31
  • Contact: 10.6023/cjoc201709020
  • Supported by:

    Project supported by the National Natrual Science Foundation of China (No. 31371750).

Among the numerous bio-active species which are involved in the various chemical reactions in our body, reactive oxygen species (ROS) are a class of important biological species, which are oxidative. ROS can maintain the intracellular redox balance and are tightly related with the cell growth and death. Hence, the fluorescence detection of intracellular ROS has attracted wide attention. However, owining to the inherent features of ROS, such as the short lifetime and high reactivity, fluorescence analysis of ROS is always faced with some problems, like low selectivity and side reactions. Herein, the development of small molecular fluorescent probes for intracellular ROS over the past decade is summarized, and the design mechanisms and bio-applications of these probes are emphasized.

Key words: reactive oxygen species (ROS), fluorescent sensor, intracellular imaging