Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1763-1771.DOI: 10.6023/cjoc201712027 Previous Articles     Next Articles



严映坤a, 徐侨b, 高扬a, 刘辉a, 唐孝荣a   

  1. a 西华大学理学院 成都 610039;
    b 西华大学食品与生物工程学院 成都 610039
  • 收稿日期:2017-12-19 修回日期:2018-01-31 发布日期:2018-03-16
  • 通讯作者: 唐孝荣

Synthesis and Study on Insecticidal Activity of New Heterocyclic Chalcone Derivatives

Yan Yingkuna, Xu Qiaob, Gao Yanga, Liu Huia, Tang Xiaoronga   

  1. a School of Science, Xinhua University, Chengdu 610039;
    b School of Food and Bioengineering, Xihua University, Chengdu 610039
  • Received:2017-12-19 Revised:2018-01-31 Published:2018-03-16
  • Contact: 10.6023/cjoc201712027

Twenty one new heterocyclic chalcone derivatives were synthesized by the Claisen-Schmidt condensation and ammonolysis of acyl chloride using heterocyclic aldehyde and amino substituted acetophenone as well as acyl chloride as raw materials. The laboratorial bioassay of the insecticidal activity of the synthesized compounds was performed using Aphis craccivora and Pieris rapae as targets. The results showed that most of them had significant insecticidal activity against the two pests. Among them, the median lethal concentration (LC50) of compound 2l was 1.6 μg/mL against Aphis craccivora, whose insecticidal efficacy was superior to imidacloprid with LC50 of 1.8 μg/mL. The insecticidal efficacy of 1b, 1f, 2j and 2n was also close to imidacloprid against Aphis craccivora. The LC50 values of compounds 1f and 2m against Aphis craccivora and Pieris rapae were 6.6 μg/mL and 8.5 μg/mL, respectively and their insecticidal activity exceeded β-cypermethrin, whose LC50 was 9.2 μg/mL.

Key words: heterocyclic chalcone, insecticidal activity, Aphis craccivora, Pieris rapae