Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1665-1672.DOI: 10.6023/cjoc202001029 Previous Articles     Next Articles


梁凯a, 周钱a, 荀校a, 倪亚丹a, 李金峰a, 石玉军a, 周环宇a, 吴新星a, 石健b, 高磊a, 戴红a   

  1. a 南通大学化学化工学院 江苏南通 226019;
    b 南通大学分析测试中心 江苏南通 226019
  • 收稿日期:2020-01-22 修回日期:2020-02-25 发布日期:2020-03-04
  • 通讯作者: 石玉军, 吴新星, 戴红;;
  • 基金资助:

Synthesis and Insecticidal Activities of Novel Pyrazole Amide Derivatives Containing a Thiazole Unit

Liang Kaia, Zhou Qiana, Xun Xiaoa, Ni Yadana, Li Jinfenga, Shi Yujuna, Zhou Huanyua, Wu Xinxinga, Shi Jianb, Gao Leia, Dai Honga   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangshu 226019;
    b Analysis and Testing Center, Nantong University, Nantong, Jiangshu 226019
  • Received:2020-01-22 Revised:2020-02-25 Published:2020-03-04
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12019060) and the Program of High-level Talents of Nantong University (No. 03083031).

In search of novel pyrazole amide compounds possessing good biological activities, a series of pyrazole amides were synthesized by introducing thiazole unit into pyrazole ring via amido bond, based on the lead of tebufenpyrad. The title compounds were structurually confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay displayed that all the title compounds exhibited 100% insecticidal activities against Oriental armyworm at 500 μg/mL. At the concentration of 500 μg/mL, seven compounds showed 70%~100% mortality rate against Aphis medicaginis. In addition, three compounds had 40%~50% insecticidal activity against Tetranychus cinnabarinus at 500 μg/mL.

Key words: thiazole, pyrazole amide, synthesis, insecticidal activity