Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 2054-2059.DOI: 10.6023/cjoc201801015 Previous Articles     Next Articles



白飞成, 胡德庆, 刘云云, 韦丽   

  1. 江西师范大学化学化工学院 南昌 330022
  • 收稿日期:2018-01-08 修回日期:2018-03-21 发布日期:2018-04-27
  • 通讯作者: 韦丽
  • 基金资助:


One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones

Bai Feicheng, Hu Deqing, Liu Yunyun, Wei Li   

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2018-01-08 Revised:2018-03-21 Published:2018-04-27
  • Contact: 10.6023/cjoc201801015
  • Supported by:

    Project supported by the Department of Education of Jiangxi Province (No. GJJ160328) and the Doctoral Start-up Fund of Jiangxi Normal University.

A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N, N-dimethylformamide dimethyl acetal (DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.

Key words: 4-hydroxyl-2-pyridone, multicomponent reaction, dimethyl 3-oxopentanedioate, one-pot synthesis