Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins

doi:10.6023/cjoc201910039

Abstract

Organocatalytic multicomponent asymmetric cascade reaction is generally regarded as one of the most effective methods for constructing complex chiral compounds. Bifunctional chiral catalysts are an important class of single-molecule double-activated organic catalysts, which can simultaneously activate hydrogen bonds of multiple reactive substrates to achieve the formation of multiple new bonds and stereoselective control of multiple chiral centers. Nitroolefins are important organic reaction synthons, which can participate in a variety of asymmetric cascade reactions by hydrogen bond activation. In this paper, the recent advances in nitroolefins-involved multicomponent asymmetric cascade reactions catalyzed by bifunctional organocatalysts involving chiral bifunctional thiourea amines, squaramide amines and other bifunctional catalysts are reviewed. Specifically, the catalytic systems, characteristics, mechanisms are systematically expounded, and the application of this research field is also prospected.

Key words: bifunctional catalysts, hydrogen-bond activation, nitroolefin, multicomponent reactions, asymmetric synthesis, cascade reaction

Cite this article

Yan Lijun, Yan Yuxin, Chen Xuebing, Wang Yongchao. Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins[J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 856-872.

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