Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1833-1836.DOI: 10.6023/cjoc201801042 Previous Articles     Next Articles

Notes

胆木枝叶中一个新的吲哚生物碱类化合物

柳庆龙a,b,c, 陈阿红a,b,c, 蒋芝华a,b,c, 马延蕾a,b,c, 唐进英a,b,c, 徐伟c, 刘艳萍a,b, 付艳辉a,b,c   

  1. a 海南师范大学 热带药用植物化学教育部重点实验室 海口 571158;
    b 海南师范大学 南药资源产业化关键技术研究海口市重点实验室 海口 571158;
    c 福建中医药大学药学院 福州 350122
  • 收稿日期:2018-01-28 修回日期:2018-03-17 发布日期:2018-04-04
  • 通讯作者: 刘艳萍, 付艳辉 E-mail:fuyanhui80@163.com;liuyanpinghs@163.com
  • 基金资助:

    海南省应用技术研发与示范推广专项(No.ZDXM2015063)、国家自然科学基金(Nos.21662011和31660097)和教育创新发展团队(No.IRT-16R19)资助项目.

A New Indole Alkaloid from the Stems and Leaves of Nauclea officinalis

Liu Qinglonga,b,c, Chen Ahonga,b,c, Jiang Zhihuaa,b,c, Ma Yanleia,b,c, Tang Jinyinga,b,c, Xu Weic, Liu Yanpinga,b, Fu Yanhuia,b,c   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158;
    c College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122
  • Received:2018-01-28 Revised:2018-03-17 Published:2018-04-04
  • Contact: 10.6023/cjoc201801042 E-mail:fuyanhui80@163.com;liuyanpinghs@163.com
  • Supported by:

    Project supported by the Applied Technology Research and Development and Demonstration Project of Hainan Province (No. ZDXM2015063), the National Natural Science Foundation of China (Nos. 21662011 and 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19).

A new indole alkaloid, nauclofficine (1), together with three known alkaloids, naucleamide A (2), naucleamide D (3) and latifoliamide A (4), were isolated from the stems and leaves of Nauclea officinalis. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from N. officinalis for the first time. The cytotoxicities of compounds 1~4 were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Research results showed that compounds 1~4 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.

Key words: Nauclea, Nauclea officinalis, nauclofficine, cytotoxicities