Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

doi:10.6023/cjoc201801049

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1740-1748.DOI: 10.6023/cjoc201801049 Previous Articles Next Articles

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通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺

谭家希, 郭也, 曾飞, 陈观荣, 谢龙勇, 何卫民

湖南省银杏工程技术研究中心湖南科技学院永州 425100

收稿日期:2018-01-31 修回日期:2018-03-18 发布日期:2018-03-29
通讯作者: 何卫民 E-mail:weiminhe2016@yeah.net
基金资助:
国家自然科学基金（Nos.21602055，21302048）、湖南省高校创新团队（No.2012-318）、湖南省教育厅重点建设学科资助项目.

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin

Hunan Provincial Engineering Research Center for Ginkgo biloba, Hunan University of Science and Engineering, Yongzhou 425100

Received:2018-01-31 Revised:2018-03-18 Published:2018-03-29
Contact: 10.6023/cjoc201801049 E-mail:weiminhe2016@yeah.net
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21602055, 21302048), the Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (No. 2012-318) and the Construct Program of the Key Discipline in Hunan Province.

1. Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates.PDF(1479KB)

Abstract

A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling reagents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.

Key words: amides, carboxylic acids, isothiocyanates, synthetic methods, electron-deficient amides

Cite this article

Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin. Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates[J]. Chin. J. Org. Chem., 2018, 38(7): 1740-1748.

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通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

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