Recent Progress on the Synthesis of Phenols through C-H Hydroxylation of Aromatics

doi:10.6023/cjoc201803022

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1930-1939.DOI: 10.6023/cjoc201803022 Previous Articles Next Articles

Special Issue: 碳氢活化合辑2018-2019

Reviews

芳香环C-H羟基化制备苯酚方法的研究进展

钱少平, 马尧睿, 高姗姗, 骆钧飞

宁波大学材料科学与化学工程学院宁波 315211

收稿日期:2018-03-15 修回日期:2018-04-23 发布日期:2018-05-03
通讯作者: 骆钧飞 E-mail:luojunfei@nbu.edu.cn
基金资助:
宁波大学人才引进基金（No.ZX2016000748）、宁波大学王宽诚幸福基金资助项目.

Recent Progress on the Synthesis of Phenols through C-H Hydroxylation of Aromatics

Qian Shaoping, Ma Yaorui, Gao Shanshan, Luo Junfei

School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211

Received:2018-03-15 Revised:2018-04-23 Published:2018-05-03
Contact: 10.6023/cjoc201803022 E-mail:luojunfei@nbu.edu.cn
Supported by:
Project supported by the research Funds of Ningbo University (No. ZX2016000748) and the K. C. Wong Magna Fund in Ningbo University.

Phenols are important central motifs that are abundant in many natural products, pharmaceuticals and agrochemicals. Moreover, the high reactivity of phenol derivatives makes them versatile building blocks for organic synthesis. Over the past decade, the synthesis of phenol derivatives via C-H hydroxylation of aromatics has received much attention due to its potential as an atom efficient methodology. Herein, the research advances on the C-H hydroxylation of aromatics are reviewed categorized by the types of hydroxylation source used. Detailed substrate scopes and reaction mechanisms will be discussed, as well as the limitations of current procedures and the prospects for the future.

Key words: transition-metal catalysis, C-H activation, hydroxylation, phenols

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Qian Shaoping, Ma Yaorui, Gao Shanshan, Luo Junfei. Recent Progress on the Synthesis of Phenols through C-H Hydroxylation of Aromatics[J]. Chin. J. Org. Chem., 2018, 38(8): 1930-1939.

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芳香环C-H羟基化制备苯酚方法的研究进展

Recent Progress on the Synthesis of Phenols through C-H Hydroxylation of Aromatics

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