Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 3123-3126.DOI: 10.6023/cjoc201804037 Previous Articles     Next Articles



王翔, 陈平, 支三军, 胡华友, 阚玉和   

  1. 淮阴师范学院化学化工学院 江苏省低维材料化学重点实验室 淮安 223300
  • 收稿日期:2018-04-18 修回日期:2018-06-13 发布日期:2018-06-29
  • 通讯作者: 王翔
  • 基金资助:


CBr4-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles

Wang Xiang, Chen Ping, Zhi Sanjun, Hu Huayou, Kan Yuhe   

  1. Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai'an 223300
  • Received:2018-04-18 Revised:2018-06-13 Published:2018-06-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 51403073), the Department of Education of Jiangsu Province (No. 16KJB150006) and the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials (No. JSKC15145).

2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitrile derivatives not only exhibit a variety of important biological activities, but also are important intermediates in organic synthesis. The CBr4-promoted reaction of aromatic aldehydes with 2-(1H-benzo[d] imidazol-2-yl) acetonitrile to obtain 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles was developed. Structurally diverse 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles were obtained in moderate to good yields (74%~96%) under mild conditions. This method has the advantages of operational simplicity and wide substrate scope.

Key words: benzimidazol, carbon tetrabromide, acrylonitrile, Knoevenagel condensation