Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 377-389.DOI: 10.6023/cjoc201806031 Previous Articles     Next Articles

ARTICLE

多组分反应合成紫杉醇侧链及其在合成紫杉醇衍生物中的应用

盛家骏a, 于雅楠a, 王信a,b, 钱宇b, 符立梧c, 赵芸a, 马明亮a, 胡文浩a,b   

  1. a 华东师范大学上海分子治疗与新药创制工程技术研究中心 上海 200062;
    b 中山大学药学院 广州 510006;
    c 中山大学肿瘤防治中心 广州 510060
  • 收稿日期:2018-07-24 修回日期:2018-12-17 出版日期:2019-02-25 发布日期:2018-12-21
  • 通讯作者: 马明亮, 胡文浩 E-mail:mlma@brain.ecnu.edu.cn;huwh9@mail.sysu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21572067,21332003)资助项目.

Synthesis of Paclitaxel Side Chain via Multi-Component Reaction and Its Application to the Synthesis of Paclitaxel Analogues

Sheng Jiajuna, Yu Ya'nana, Wang Xina,b, Qian Yub, Fu Liwuc, Zhao Yuna, Ma Minglianga, Hu Wenhaoa,b   

  1. a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;
    b School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006;
    c Cancer Center, Sun Yat-sen University, Guangzhou 510060
  • Received:2018-07-24 Revised:2018-12-17 Online:2019-02-25 Published:2018-12-21
  • Contact: 10.6023/cjoc201806031 E-mail:mlma@brain.ecnu.edu.cn;huwh9@mail.sysu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21572067, 21332003).

Under the catalysis of Cu(OTf)2, a hydroxy ylide trapping based multi-component reaction using water, diazoacetates, aromatic aldehydes and aromatic amines was successfully carried out to construct α-hydroxy-β-amino acid ester skeleton in one step. The taxol oxazolidine-type side chains were efficiently synthesized after further chemical transformations. Moreover, 14 taxane derivatives were synthesized through esterification of obtained side chains and 7-O-(triethylsilyl) baccatin Ⅲ or 7,10-dimethoxy-10-beacetyl baccatin Ⅲ, and several novel compounds with excellent activity were discovered in the test of anti-tumor activity. In this paper, combining the methodology and application of multi-component reaction, a highly efficient method for synthesizing paclitaxel side chain derivatives was developed, which was applied into the semi-synthesis of paclitaxel analogues. This research provided a new approach to the study of structure-activity relationship and had potential application value.

Key words: taxol side chain, paclitaxel analogues, multi-component reaction, hydroxy ylide