Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives

doi:10.6023/cjoc201507011

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (1): 222-228.DOI: 10.6023/cjoc201507011 Previous Articles Next Articles

Notes

多组分反应合成螺吲哚-吡喃并[2,3-c]吡唑类化合物的研究

冯俊, 阿布拉江·克依木, 马夏冰, 李文博, 麦麦提艾力·奥布力

新疆大学化学化工学院新疆石油天然气精细化工教育部&自治区重点实验室乌鲁木齐 830046

收稿日期:2015-07-15 修回日期:2015-08-29 发布日期:2015-09-06
通讯作者: 阿布拉江·克依木 E-mail:ablajan209@hotmail.com
基金资助:
新疆教育部研究生科研创新项目基金(No. XJGRI2014019)、国家自然科学基金(No. 21462041)和新疆维吾尔自治区天山英才培养计划资助项目.

Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives

Feng Jun, Ablajan Keyume, Ma Xiabing, Li Wenbo, Obul Mamateli

Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Received:2015-07-15 Revised:2015-08-29 Published:2015-09-06
Supported by:
Project supported by the Graduate Student Research Innovation Project of Xinjiang Educational Department (No. XJGRI2014019), the National Natural Science Foundation of China (No. 21462041), and the Tianshan Talent Cultivation Project of Xinjiang Uyghur Autonomous Region.

1. Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives.PDF(1617KB)

Abstract

A highly efficient strategy for the one-pot synthesis of multi-substituted spirooxindol-pyrano[2,3-c]pyrazole derivatives was developed. The product formed in good yield from the reaction of acetylenedicarboxylate, hydrazine, isatin, and (E)-1-methylthio-1-methylamino-2-nitroethylene in the presence of Et₃N catalyst. This simple and convenient method could also be used to prepare similar types of product.

Key words: spirooxindole, multi-component reaction, one-pot synthesis, pyrano[2,3-c]pyrazole

Cite this article

Feng Jun, Ablajan Keyume, Ma Xiabing, Li Wenbo, Obul Mamateli. Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives[J]. Chin. J. Org. Chem., 2016, 36(1): 222-228.

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多组分反应合成螺吲哚-吡喃并[2,3-c]吡唑类化合物的研究

Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives

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