Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2335-2347.DOI: 10.6023/cjoc201806033 Previous Articles     Next Articles

Special Issue: 合成科学

Reviews

真菌三萜及甾体的生物合成研究进展

高铫晖, 王高乾, 黄蕙芸, 高昊, 姚新生, 胡丹   

  1. 暨南大学药学院 中药及天然药物研究所 广州 510632
  • 收稿日期:2018-06-20 修回日期:2018-07-06 出版日期:2018-09-25 发布日期:2018-07-16
  • 通讯作者: 胡丹 E-mail:thudan@jnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.31670036)资助项目.

Biosynthesis of Fungal Triterpenoids and Steroids

Gao Yaohui, Wang Gaoqian, Huang Huiyun, Gao Hao, Yao Xinsheng, Hu Dan   

  1. Institute of Traditional Chinese Medicine and Natural Products, School of Pharmacy, Jinan University, Guangzhou 510632
  • Received:2018-06-20 Revised:2018-07-06 Online:2018-09-25 Published:2018-07-16
  • Contact: 10.6023/cjoc201806033 E-mail:thudan@jnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31670036).

Triterpenoids and steroids are one of the largest classes of natural products composed of six isoprene units, with various chemical structures as well as wide range of biological activities. Fungi serves as important sources for triterpenoids and steroids. However, compared with plants, the types of triterpenoid skeletons discovered in fungi are much fewer, suggesting that there is a large research space. Genome mining has become an important method of discovering novel natural products in the post-genomic era, which uses the genes with similar functional to identify the target genes with new functions. With the rapid development of high-throughput sequencing and biological information technology, biosynthetic pathways of some triterpenoids and steroids with important biological activities have been elucidated in recent years, which build the foundations for the discovery of new triterpenoids or steroids from fungi via genome mining. The recent advances in the biosynthesis of fungal triterpenoids and steroids are mainly introduced.

Key words: triterpenoids, steroids, fungi, biosynthesis, genome mining