Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 74-83.DOI: 10.6023/cjoc201808046 Previous Articles     Next Articles

Special Issue: 庆祝陈庆云院士九十华诞

Reviews

芳基三氟甲基酮类化合物的合成进展

张洁雨, 柯求敏, 陈家英, 何平, 严国兵   

  1. 丽水学院化学系 丽水 323000
  • 收稿日期:2018-08-31 修回日期:2018-10-16 出版日期:2019-01-25 发布日期:2018-10-26
  • 通讯作者: 严国兵 E-mail:gbyan@lsu.edu.cn
  • 基金资助:

    浙江省自然科学基金(No.LY18B020005)资助项目.

Recent Progress in the Synthesis of Aryl Trifluoromethyl Ketones

Zhang Jieyu, Ke Qiumin, Chen Jiaying, He Ping, Yan Guobing   

  1. Department of Chemistry, Lishui University, Lishui 323000
  • Received:2018-08-31 Revised:2018-10-16 Online:2019-01-25 Published:2018-10-26
  • Contact: 10.6023/cjoc201808046 E-mail:gbyan@lsu.edu.cn
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (No. LY18B020005).

Aryl trifluoromethyl ketone is a very important intermediate in the organic synthesis. Much attention has been attracted from researchers, due to its potential bioactivity. In this paper, the recent progress in the synthesis of aryl trifluoromethyl ketone is reviewed, including the oxidant of α-trifluoromethyl alcohols, trifluoromethylation of carboxylic acid derivatives, trifluoroacetylation of organometallic reagents, electron-rich aromatics, aryl halides and aryl diazonium salts, and the reaction mechanisms are also discussed.

Key words: aryl trifluoromethyl ketones, trifluoroacetylation, coupling reaction, reaction mechanism