Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 929-939.DOI: 10.6023/cjoc201810033 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019

Reviews

以三氟乙酸及其衍生物为三氟甲基源的三氟甲基化反应研究进展

季小明a, 史广法a, 张扬会a,b   

  1. a 同济大学化学科学与工程学院 上海 200092;
    b 上海市化学品分析、风险评估与控制重点实验室 同济大学 上海 200092
  • 收稿日期:2018-10-25 修回日期:2018-12-06 出版日期:2019-04-25 发布日期:2018-12-21
  • 通讯作者: 张扬会 E-mail:zhangyanghui@tongji.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21372176,21672162)资助项目.

Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF3-Sources

Ji Xiaominga, Shi Guangfaa, Zhang Yanghuia,b   

  1. a School of Chemical Science and Engineering, Tongji University, Shanghai 200092;
    b Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092
  • Received:2018-10-25 Revised:2018-12-06 Online:2019-04-25 Published:2018-12-21
  • Contact: 10.6023/cjoc201810033 E-mail:zhangyanghui@tongji.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21372176,21672162).

Organic molecules containing trifluoromethyl groups often exhibit unique physical and chemical properties, and have found extensive applications. Trifluoroacetic acid and its derivatives have advantages including low cost, ready availability and high stability. Furthermore, CO2 is the byproduct. Therefore, trifluoroacetic acid and its derivatives are ideal trifluoromethylating reagents, and have great application potentials. The progress of trifluoromethylation reactions using trifluoroacetic acid and its derivatives as CF3-sources is reviewed, including the reactions of C-X (X=Br and I), C-H, and C=X (X=C, O). The mechanisms are also introduced.

Key words: trifluoroacetic acid, CF3-sources, trifluoromethylation reaction, C-H activation