Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3517-3535.DOI: 10.6023/cjoc202003057 Previous Articles     Next Articles

Special Issue: 创刊四十周年专辑


吴勇杰, 史炳锋   

  1. 浙江大学化学系 杭州 310027
  • 收稿日期:2020-03-25 修回日期:2020-04-30 发布日期:2020-05-11
  • 通讯作者: 史炳锋
  • 基金资助:

Transition Metal-Catalyzed C-H Activation via Imine-Based Transient Directing Group Strategy

Wu Yongjie, Shi Bingfeng   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027
  • Received:2020-03-25 Revised:2020-04-30 Published:2020-05-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21925109, 21772170), the Outstanding Young Talents of Zhejiang Province (No. ZJWR0108), the Fundamental Research Funds for the Central Universities (No. 2018XZZX001-02) and the Natural Science Foundation of Zhejiang Province (No. LR17B020001).

In the past decades, transition metal-catalyzed C—H activation has experienced tremendous growth and revolutionized the field of organic synthesis. Several elegant strategies have been developed to promote reactivity and control precise site-selectivity. Among which, transient directing group strategy has been recognized to be an efficient and powerful approach for selective C—H functionalization. In contrast to traditional directing groups with covalent linkage, transient directing group strategy circumvents the covalent installation and removal of directing groups, which significantly improve the synthetic efficiency and broaden the range of synthetic applications. The recent advances in imine-based transition directing groups are summarized, providing an overview of recent achievements in this cutting-edge research field over the past few years. For clarity, it is classified into two sections according to the type of substrate and the type of activated hydrocarbon bond. Emphasis is placed on the fully discussion of various transient directing groups and their applications. Finally, the limitations of previous works and perspectives on this cutting-edge area are also described.

Key words: transient directing group strategy, transition metal, C-H activation, imine, directing groups