Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3299-3303.DOI: 10.6023/cjoc201903032 Previous Articles     Next Articles


王翔*(), 陈平, 支三军, 胡华友, 阚玉和, 张载超*()   

  1. 淮阴师范学院化学化工学院 江苏省低维材料化学重点实验室 江苏淮安 223300
  • 收稿日期:2019-03-17 发布日期:2019-06-19
  • 通讯作者: 王翔,张载超;
  • 基金资助:

One-Pot Three-Component Synthesis of 3-(1H-Benzo[d]imidazol-2-yl)chromen Derivatives

Wang Xiang*(), Chen Ping, Zhi Sanjun, Hu Huayou, Kan Yuhe, Zhang Zaichao*()   

  1. Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai'an, Jiangsu 223300
  • Received:2019-03-17 Published:2019-06-19
  • Contact: Wang Xiang,Zhang Zaichao;
  • Supported by:
    the National Natural Science Foundation of China(21601061);the National Natural Science Foundation of China(51403073);the Department of Education of Jiangsu Province(16KJB150006);the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials(JSKC15145)

Benzoimidazole and chromen derivatives exhibit a variety of important biological activities. Chromens incorporating benzoimidazole moiety have high Rho kinase inhibitory activity. However, the effective synthetic method for the preparation of these compounds is rare. The efficient synthesis of new substituted 3-(1H-benzo[d]imidazol-2-yl)-4H-chromens in 48%~89% yields via one-pot, three-component reaction of 2-(1H-benzo[d]imidazol-2-yl)acetonitrile with aromatic aldehydes and 5, 5-dimethylcyclohexane-1, 3-dione was studied. This reaction was carried out in EtOH in the presence of pyridine under reflux conditions. All reactions were completed within 1 to 3 h.

Key words: benzoimidazole, chromen, multicomponent reaction, heterocyclic skeleton