Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2786-2795.DOI: 10.6023/cjoc201903060 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑

REVIEW

用于人血清白蛋白检测的有机荧光分子探针的研究进展

吕陶玉赜, 朱康宁, 刘斌()   

  1. 深圳大学材料学院 深圳 518060
  • 收稿日期:2019-03-27 修回日期:2019-04-26 出版日期:2019-10-25 发布日期:2019-05-21
  • 基金资助:
    国家自然科学基金资助项目(21602139)

Recent Advances of Organic Fluorescent Probes for Detection of Human Serum Albumin

Lü Taoyuze, Zhu Kangning, Liu Bin()   

  1. College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060
  • Received:2019-03-27 Revised:2019-04-26 Online:2019-10-25 Published:2019-05-21
  • Supported by:
    Project supported by the National Natural Science Foundation of China(21602139)

Human serum albumin (HSA) is the most abundant protein in human blood plasma, which plays important roles in physiological and biological processes, such as keeping the osmotic pressure and transporting small molecular ligands. The level of HSA in in biological samples especially in blood serum can reveal several health conditions, and thus, quantitative determination of HSA has vital importance for disease diagnosis. In recent years, as the rapid development of fluorescent probe technique, a great number of fluorescent probes have been reported for sensitive and selective detection of HSA. This article summarizes recent reported organic-based fluorescent probes, subsequently carefully describes the chemical structures, sensing mechanisms, spectral features, limit of detection, and binding sites, and moreover, the future developments and prospects for HSA detection by using fluorescent probes have been discussed

Key words: human serum albumin, fluorescent probes, binding sites, sensing mechanism