Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3145-3153.DOI: 10.6023/cjoc201904024 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019 有机硅化学合辑


王明凤a, 余茂栋a, 王文蜀ac, 林伟立a, 罗斐贤abc*()   

  1. a中央民族大学生命与环境科学学院 北京 100081
    b 中央民族大学转化神经科学中心 北京 100081
    c 中央民族大学化学实验中心 北京 100081
  • 收稿日期:2019-04-10 发布日期:2019-06-24
  • 通讯作者: 罗斐贤
  • 基金资助:

Cross-Coupling of C-Si Bond by Using Silyl Reagents

Wang Mingfenga, Yu Maodonga, Wang Wenshuac, Lin Weilia, Luo Feixianabc*()   

  1. a College of Life and Environment Science, Minzu University of China, Beijing 100081
    b MUC Center on Translational Neuroscience, Minzu University of China, Beijing 100081
    c Experimental Center of Chemistry, Minzu University of China, Beijing 100081
  • Received:2019-04-10 Published:2019-06-24
  • Contact: Luo Feixian
  • Supported by:
    the National Natural Science Foundation of China(21901263);the National Natural Science Foundation of China(91744206);the Promotion Program for Young Teacher in Science and Technology Research of Minzu University of China(2019QNPY60)

Organosilanes have been widely applied in synthetic chemistry, pharmaceuticals, agrochemicals, and materials due to the special properties. Several synthetic strategies including nucleophilic substitution, hydrosilylation of alkene, and C-H silylation have been developed. In recent years, significant progress has advanced in the cross-coupling of C-Si bond for the synthesis of organosilanes, especially in the break-through of the cross-coupling of C(sp3)-Si bond. It has become one of the hottest issues in synthetic chemistry. The recent progress on the cross-coupling of C-Si bond by using silyl reagents is summarized. The application of silyl reagents in cross-coupling for C-Si bond formation including silyl boranes, organosilyl magnesium, organosilyl zinc, unasymetric disilanes, organosilyl aluminum and organosilyl lithium reagents is mainly discussed.

Key words: silyl reagents, cross-coupling, transition-metal catalysis, organosilanes