Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3169-3175.DOI: 10.6023/cjoc201904028 Previous Articles     Next Articles

4-二甲氨基吡啶促进的一锅法合成高选择性螺环丙烷吡唑啉酮衍生物

梁杰, 马会芳, 阿布拉江·克依木*()   

  1. 新疆大学化学化工学院 石油天然气精细化工教育部&新疆维吾尔自治区重点实验室 乌鲁木齐 830046
  • 收稿日期:2019-04-10 出版日期:2019-11-25 发布日期:2019-07-09
  • 通讯作者: 阿布拉江·克依木 E-mail:ablajan209@hotmail.com
  • 基金资助:
    国家自然科学基金(21961038);国家自然科学基金(21462041)

High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine

Liang Jie, Ma Huifang, Ablajan Keyume*()   

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2019-04-10 Online:2019-11-25 Published:2019-07-09
  • Contact: Ablajan Keyume E-mail:ablajan209@hotmail.com
  • Supported by:
    the National Natural Science Foundation of Chin(21961038);the National Natural Science Foundation of Chin(21462041)

A 4-dimethylaminopyridine (DMAP)-promoted high stereoselectivity method for the synthesis of polysubstituted spiropropane pyrazolone was developed. A series of target compounds were synthesized from using pyrazolone, aromatic aldehyde and bromoacetate as raw materials, and DMAP as a base with high yield via three-component one-pot reaction. This reaction has the advantages of simple operation, high yield and good diastereotopic selectivity. In addition, this synthetic method is of great value for the study of spiropropane.

Key words: one-pot synthesis, multicomponent reactions, spirocyclopropane, pyrazolones, 4-dimethylaminopyridine (DMAP)