Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3105-3113.DOI: 10.6023/cjoc201904071 Previous Articles     Next Articles

天然产物Cyanolide A和Cocosolide的合成研究进展

张榴, 张梦帆, 齐陈泽, 杨震*()   

  1. 绍兴文理学院化学化工学院 浙江省精细化工与传统工艺绿色替代技术重点实验室 浙江绍兴 312000
  • 收稿日期:2019-04-29 发布日期:2019-07-09
  • 通讯作者: 杨震
  • 基金资助:

Synthetic Studies toward Natural Occurred Cyanolide A and Cocosolide

Zhang Liu, Zhang Mengfan, Qi Chenze, Yang Zhen*()   

  1. Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang 312000
  • Received:2019-04-29 Published:2019-07-09
  • Contact: Yang Zhen
  • Supported by:
    the National Natural Science Foundation of China(21302129);the Natural Science Foundation of Zhejiang Province(LQ13B020002)

Cyanolide A and cocosolide, two 16-membered dimeric macrolide xylopyranosides, were isolated from Guam and Papua New Guinea, respectively. Their fascinating structures and outstanding biological activities had attracted great attentions from chemists. The synthesis of cyanolide A and cocosolide is reviewed based on the construction methods of tetrahydropyran ring, which involves oxo-Michael addition reaction, oxo-carbenium cyclization and transition-metal catalyzed cyclization reactions.

Key words: cyanolide A, cocosolide, total synthesis, oxo-Michael addition, oxo-carbenium cyclization reaction, transition-metal catalyzed cyclization reaction