Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3328-3337.DOI: 10.6023/cjoc201907005 Previous Articles     Next Articles

过渡金属催化氧气氧插入反应研究进展

吴锦雯, 朱佳雯, 李慧, 吴春雷, 沈润溥, 余乐茂   

  1. 绍兴文理学院化学化工学院 浙江绍兴 312000
  • 收稿日期:2019-07-03 修回日期:2019-08-11 出版日期:2019-12-25 发布日期:2019-08-30
  • 通讯作者: 沈润溥, 余乐茂 E-mail:yulm@usx.edu.cn;srunpu@usx.edu.cn
  • 基金资助:
    浙江省公益技术项目(No.LGG19B02002)和绍兴文理学院博士科研启动基金(No.20185018)资助项目.

Recent Advances of Transition Metal-Catalyzed Aerobic Oxygenation with Molecular Oxygen

Wu Jinwen, Zhu Jiawen, Li Hui, Wu Chunlei, Shen Runpu, Yu Lemao   

  1. College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, Zhejiang 312000
  • Received:2019-07-03 Revised:2019-08-11 Online:2019-12-25 Published:2019-08-30
  • Supported by:
    Project supported by the Public Projects of Zhejiang Province of China (No. LGG19B02002) and the Doctoral Research Initiation Fund of Shaoxing University (No. 20185018).

Oxygen-bearing structures are attractive synthetic targets due to their wide presence in a great number of natural products and biologically active molecules, and their role as useful synthons in organic synthesis. Thus, the preparation of O-bearing compounds has been an important topic. Transition metal-catalyzed aerobic oxygenation strategy has emerged as a novel and efficient methodology for constructing C-C bonds and C-heteroatom bonds. This strategy has become one of the most important and useful synthetic method in organic synthesis of O-bearing compounds. Based on the previous work of our group and others, herein, the new applications of transition metal-catalyzed oxygenation of C-H bond activation and C-C bond cleavage with oxygen as oxygen source are discussed. The recent progress in trans-metal catalytic oxygen insertion of ketones, aldehydes, alkene, alkynes, arene and aromatic heterocyclic compounds has been reviewed. Transition metal-catalysts can initiate oxygen insertion reaction of free radical pathway and realize selective insertion of oxygen radicals under oxygen oxidation. These reactions are characterized by mild conditions, environmental protection and highly atom economy.

Key words: transition metal catalysis, oxygen oxidation, C-H activation, C-C cleavage, oxygenated reaction, radical pathway