Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1697-1703.DOI: 10.6023/cjoc201912041 Previous Articles     Next Articles


阿布力米提·阿布都卡德尔, 汪荣, 买尔哈巴·买买提, 刘晨江   

  1. 新疆大学化学化工学院 乌鲁木齐 830046
  • 收稿日期:2019-12-18 修回日期:2020-02-05 发布日期:2020-03-04
  • 通讯作者: 阿布力米提·阿布都卡德尔, 刘晨江;
  • 基金资助:

FeCl2-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

Abdukader Ablimit, Wang Rong, Mamat Marhaba, Liu Chenjiang   

  1. College of Chemical and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2019-12-18 Revised:2020-02-05 Published:2020-03-04
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21562039).

A simple, practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl2-catalyzed direct aerobic oxidative has been developed. Nineteen novel multi-substituted 3,5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated. The products were get with about 70%~90% yields under mild conditions. The structures of products were fully characterized by 1H NMR, 13C NMR, elemental analysis and X-ray crystal.

Key words: iron catalysis, oxygen oxidation, isoxazole, heterocycle, N-O bond formation