Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1725-1730.DOI: 10.6023/cjoc202001033 Previous Articles     Next Articles


董玮a, 王欣a, 葛泽梅a, 和芳b, 李润涛a   

  1. a 北京大学药学院 天然药物及仿生药物国家重点实验室 北京 100191;
    b 北京创立科创医药技术开发有限公司 北京 100029
  • 收稿日期:2020-01-29 修回日期:2020-03-17 发布日期:2020-04-10
  • 通讯作者: 李润涛
  • 基金资助:

Efficient Synthesis of Wogonin

Dong Weia, Wang Xina, Ge Zemeia, He Fangb, Li Runtaoa   

  1. a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191;
    b Beijing Supertrack Pharma-Tech Co., LTD, Beijing 100029
  • Received:2020-01-29 Revised:2020-03-17 Published:2020-04-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 81673287).

Wogonin is an important flavonoid with a wide range of pharmacological activities, and its research has received increasing attention. The large amount of wogonin is the basis of in-depth research on it, but currently there are problems, such as difficulty in extracting from natural products, difficult to obtain fully synthetic raw materials, harsh reaction conditions, use of valuable and toxic reagents, difficulty in isolation and purification, or low yields. Herein, an efficient synthesis of wogonin from benzene-1,3,5-triol as starting material via seven steps with total yield of 58% was reported. This method possesses advantages including available starting materials, mild reaction conditions, simple operation and no column chromatography purification, which will provide a foundation for the large-scale preparation and in-depth study of wogonin.

Key words: wogonin, benzene-1,3,5-triol, chrysin, total synthesis