Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2863-2870.DOI: 10.6023/cjoc202004048 Previous Articles     Next Articles


林聪, 高震博, 腾秋汛, 薛博文, 李小花, 高飞, 申亮   

  1. 江西科技师范大学化学化工学院 南昌 330013
  • 收稿日期:2020-04-29 修回日期:2020-06-04 发布日期:2020-06-20
  • 通讯作者: 林聪, 申亮;
  • 基金资助:

Synthesis of Vinyl-Substituted Dihydroisoquinolone via Ru(II)-Catalyzed C—H Functionalization/Annulation of Imidates

Lin Cong, Gao Zhenbo, Teng Qiuxun, Xue Bowen, Li Xiaohua, Gao Fei, Shen Liang   

  1. College of Chemistry and Chemical Engineering, Jiangxi Science & Technology Normal University, Nanchang 330013
  • Received:2020-04-29 Revised:2020-06-04 Published:2020-06-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 51963010, 21704036) and the Natural Science Foundation of Jiangxi Province (No. 20202BABL213005).

An efficient and powerful approach for the construction of vinyl-substituted dihydroisoquinolone derivatives through ruthenium-catalyzed tandem C—H functionalization/annulation of imidates has been demonstrated. Various substituted functional groups of imidates could be well tolerated in this new transformation, delivering the corresponding products in moderate to good yields. This method represents the first successful example of Ru(II)-catalyzed C—H functionalization/an-nulation of imidates with 4-vinyl-1,3-dioxolan-2-one to the efficient synthesis of 3-vinyl-3,4-dihydroisoquinolin-1(2H)-ones.

Key words: vinyl-substituted dihydroisoquinolone, ruthenium-catalysis, C-H functionalization, imidate, 4-vinyl-1,3-di-oxolan-2-one