Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2912-2918.DOI: 10.6023/cjoc202005004 Previous Articles     Next Articles


许秀枝a, 张帆b, 黄胜a, 张志强a, 柯方a   

  1. a 福建医科大学药学院 福建省天然药物药理学重点实验室 福州 350004;
    b 福建医科大学附属第一医院肿瘤内科 福州 350005
  • 收稿日期:2020-05-02 修回日期:2020-06-12 发布日期:2020-07-17
  • 通讯作者: 许秀枝, 柯方;
  • 基金资助:

Visible-Light Promoted Hydroxylation of Aryl Halides under Mild Reaction Conditions in Neat Water

Xu Xiuzhia, Zhang Fanb, Huang Shenga, Zhang Zhiqianga, Ke Fanga   

  1. a Fujian Provincial Key Laboratory of Natural Medicine Pharmacolog, Department of Pharmacy, Fujian Medical University, Fuzhou 350004;
    b The First Affiliated Hospital of Fujian Medical University Oncology, Fuzhou 35000
  • Received:2020-05-02 Revised:2020-06-12 Published:2020-07-17
  • Supported by:
    Project supported by the Natural Science Foundation of Fujian Province (Nos. 2016Y9052, 2016Y9053, 2017J01820, 2017-1-64).

A novel visible-light-introduced reaction for the construction of phenols via hydroxylation of aryl halides has been developed. The reaction has been achieved in high yield under mild conditions by using iodine as photocatalyst, which is cheap, easy to handle and environmentally friendly. A variety of phenols were obtained in up to 92% yields. Moreover, aryl chlorides were also successfully employed as substrates, affording the target phenols in good isolated yields. It might provide promising protocol for the synthesis of phenol derivatives. Its application was performed by the synthesis of 5-acetyl-4-hy-droxy-2-methoxybenzyl diisopropylcarbamodithioate, which displayed significant anti-proliferation effect.

Key words: visible-light promoted, iodine, aryl halides, hydroxylation