Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3166-3176.DOI: 10.6023/cjoc202005028 Previous Articles     Next Articles


李健a,b, 何龙a, 周志强a, 甄艳霞a, 谢卫青a   

  1. a 西北农林科技大学化学与药学院 陕西省天然产物化学生物学重点实验室 陕西杨陵 712100;
    b 西北农林科技大学植物保护学院 陕西杨陵 712100
  • 收稿日期:2020-05-12 修回日期:2020-06-15 发布日期:2020-06-28
  • 通讯作者: 谢卫青
  • 基金资助:

Advances in the Synthesis of Anislactone-Type Sesquiterpenes

Li Jiana,b, He Longa, Zhou Zhiqianga, Zhen Yanxiaa, Xie Weiqinga   

  1. a College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi Key Laboratory of Natural Products Chemistry and Biology, Yangling, Shaanxi 712100;
    b College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100
  • Received:2020-05-12 Revised:2020-06-15 Published:2020-06-28
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21722206, 21672171).

The anislactone type sesquiterpenoids, (-)-merrilactones A-C and anislactones A-B, contain[5-5] bicyclic carbocyclic skeleton, two γ-butyrolactone structural units, featuring congested stereocenters and a high oxidation level. This type of natural products shows potent neurotrophic activity. Particularly, (-)-merrilactone A exhibits excellent neurotrophic activity even at lower concentration with potential for treating neurodisease such as Elzheimer disease. Due to their complex caged structures and excellent biologic profiles, the synthesis of aislactone-type sesquiterpenoids has attracted considerable attention from synthetic communities. This article summarizes the recent advances in the synthesis of this type of sesquiterpenoids.

Key words: anislactone, merrilactone, sesquiterpenes, total synthesis