Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4203-4215.DOI: 10.6023/cjoc202005034 Previous Articles     Next Articles


孙泽众, 徐苗, 王云侠, 胡向东   

  1. 西北大学化学与材料科学学院 合成与天然功能分子教育部重点实验室 西安 710127
  • 收稿日期:2020-05-14 修回日期:2020-06-11 发布日期:2020-06-28
  • 通讯作者: 王云侠, 胡向东;
  • 基金资助:

Synthetic Progress of Alkaloids against Mycobacterium Tuberculosis: Pseudopteroxazole and Ileabethoxazole

Sun Zezhong, Xu Miao, Wang Yunxia, Hu Xiangdong   

  1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127
  • Received:2020-05-14 Revised:2020-06-11 Published:2020-06-28
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21772153), the Science and Technology Department of Shaanxi Province (No. S2019-JC-YB-0846) and the Key Science and Technology Innovation Team of Shaanxi Province (No. 2017KCT-37).

Two alkaloids of pseudopteroxazole and ileabethoxazole, isolated from sea whip Pseudopterogorgia elisabethae, have significant antimicrobial activity against pathogen of tuberculosis:Mycobacterium tuberculosis. These two alkaloids possess similar tetracyclic skeleton, which containing four stereocenters, a fully substituted aromatic ring and an uncommon benzoxazole unit in natural products. Significant antimicrobial activity and special molecular structures attracted extensive attentions to synthetic study on pseudopteroxazole and ileabethoxazole. The progress in the total synthesis of these two alkaloids is reviewed.

Key words: Mycobacterium tuberculosis, alkaloid, pseudopteroxazole, ileabethoxazole, total synthesis