Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 3991-4014.DOI: 10.6023/cjoc202006024 Previous Articles     Next Articles


李颖a, 马志强a,b, 徐学涛a   

  1. a 五邑大学生物科技与大健康学院 广东江门 529020;
    b 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510641
  • 收稿日期:2020-06-15 修回日期:2020-07-23 发布日期:2020-08-01
  • 通讯作者: 马志强, 徐学涛;
  • 基金资助:

Application of tert-Butanesulfinamide in Total Synthesis of Natural Products

Li Yinga, Ma Zhiqianga,b, Xu Xuetaoa   

  1. a School of Biotechnology and Health Science, Wuyi University, Jiangmen, Guangdong 529020;
    b Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641
  • Received:2020-06-15 Revised:2020-07-23 Published:2020-08-01
  • Supported by:
    Project supported by the Department of Education of Guangdong Province (No. 2019KZDXM035).

The formation of chiral amine intermediates with chiral tert-butanesulfinamide and their applications in asymmetric natural product synthesis in recent years are summarized. tert-Butanesulfinamide has attracted wide attention from chemists because it is stable, commercially available with reasonable price, ease to use, and usually induces high diastereoselectivity in the reactions involved. This review is divided into two sections, including the addition of nucleophiles to N-tert-butanesulfinyl imines and the addition of N-tert-butanesulfinyl metalloenamines to electrophiles.

Key words: tert-butanesulfinamide, chiral amine, total synthesis