Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (2): 842-848.DOI: 10.6023/cjoc202007009 Previous Articles     Next Articles



陈澍a, 任朝丽a, 田晓雨a, 张冬林a, 杨森a,
袁绍顷b, 杜晓华a, 谭成侠a,*()   

  1. a 浙江工业大学化学工程学院 杭州 310014
    b 山东同汇生物科技有限公司 济南 250000
  • 收稿日期:2020-07-03 修回日期:2020-09-23 发布日期:2020-10-12
  • 通讯作者: 谭成侠
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:

Design, Synthesis and Fungicidal Activities of Pyridyl Oxazoamide Compounds

Shu Chena, Chaoli Rena, Xiaoyu Tiana, Donglin Zhanga, Sen Yanga, Shaoqing Yuanb, Xiaohua Dua, Chengxia Tana,*()   

  1. a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
    b Shandong Tonghui Biotechnology Co., Ltd, Jinan 250000
  • Received:2020-07-03 Revised:2020-09-23 Published:2020-10-12
  • Contact: Chengxia Tan

Thirteen novel pyridyl oxazoamide compounds were synthesized using pyridine-2-formaldehyde as the starting material through cyclization, oxidation, substitution, hydrolysis, chlorination and ammonolysis reactions via the disclosed intermediate derivatization method (IDM). The structures of title compounds were characterized by 1H NMR and HRMS. Preliminary bioassay results indicated that at 100 mg/L, 7 compounds exhibited 100% fungicidal activities against Botrytis cinerea, and N-(4-fluorophenyl)-2-(pyridin-2-yl)oxazole-4-carboxamide (7b) exhibited 100% fungicidal activities against Rhizoctonia solani. Further fungicidal activity test results suggested that some of the target compounds had better fungicidal activity than azoxystrobin, which was worthy of further study.

Key words: oxazole, amide, pyridine, fungicide activity