Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 983-1001.DOI: 10.6023/cjoc202007025 Previous Articles     Next Articles

Special Issue: 有机氟化学合辑



潘军1, 吴晶晶1,*(), 吴范宏1,*()   

  1. 1 上海应用技术大学化学与环境工程学院 上海绿色氟代制药工程技术研究中心 上海 201418
  • 收稿日期:2020-07-08 修回日期:2020-08-09 发布日期:2020-09-16
  • 通讯作者: 吴晶晶, 吴范宏
  • 基金资助:
    国家自然科学基金(21672151); 国家自然科学基金(21602136)

Progress in Fluoroalkylation of Multicomponent

Jun Pan1, Jingjing Wu1,*(), Fanhong Wu1,*()   

  1. 1 Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418
  • Received:2020-07-08 Revised:2020-08-09 Published:2020-09-16
  • Contact: Jingjing Wu, Fanhong Wu
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21672151); National Natural Science Foundation of China(21602136)

Multi-component fluoroalkylation is a hot topic in organic fluorine chemistry. In the past few years, due to the development of new reagents and new methods, multi-component fluoroalkylation reactions have made great progress. It can not only introduce fluoroalkyl groups with other functional groups in one step economically and effectively, but also transform the starting materials into a variety of compounds with biological or pharmaceutical. The development of multi-component fluoroalkylation over the past decade is reviewed from seven parts: three-component difluoroalkylation reaction, three-component trifluoroalkylation reaction, three-component perfluoroalkylation reaction, three-component monofluoro- alkylation reaction, three-component fluorination and four-component fluoroalkylation and conclusion. At the same time, this kind of reaction is summarized and prospected.

Key words: multicomponent, bifunctionalization, difluoroalkylation, trifluoromethylation, perfluoroalkylation, monofluoroalkylation, fluorination