Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 1146-1152.DOI: 10.6023/cjoc202007071 Previous Articles     Next Articles



周敦1, 樊爱红1, 李翔1, 陈春霞1,*(), 孙鹏1, 彭进松1,*()   

  1. 1 东北林业大学化学化工与资源利用学院 哈尔滨 150040
  • 收稿日期:2020-07-30 修回日期:2020-10-20 发布日期:2020-11-19
  • 通讯作者: 陈春霞, 彭进松
  • 基金资助:
    中央高校基本科研业务费专项资金(2572019CG06); 中央高校基本科研业务费专项资金(2572020DR07); 黑龙江省自然科学基金(LC2018003); 黑龙江省自然科学基金(B2017002); 高等学校学科创新引智计划(111计划)(B20088)

Copper-Catalyzed Decarboxylative Cross-Coupling of Carboxylic Acids and Arylcarbamoyl Chlorides

Dun Zhou1, Aihong Fan1, Xiang Li1, Chunxia Chen1,*(), Peng Sun1, Jinsong Peng1,*()   

  1. 1 College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040
  • Received:2020-07-30 Revised:2020-10-20 Published:2020-11-19
  • Contact: Chunxia Chen, Jinsong Peng
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    Fundamental Research Funds for the Central Universities(2572019CG06); Fundamental Research Funds for the Central Universities(2572020DR07); Natural Science Foundation of Heilongjiang Province(LC2018003); Natural Science Foundation of Heilongjiang Province(B2017002); Programme of Introducing Talents of Discipline to Universities (111 Project)(B20088)

A ligand-free copper-catalyzed decarboxylative cross-coupling reaction of carboxylic acids and carbamoyl chlorides in the absence of base was developed. With CuCl2 as the catalyst, the decarboxylative cross-coupling process could be realized in benzene at 120 ℃ in 48 h. Under the standard condition, the catalytic system had good functional group tolerance, and diverse amides were obtained in good to high yields. The structures of products were elucidated by 1H NMR, 13C NMR and HRMS spectra.

Key words: copper-catalysis, decarboxylative cross-coupling, C—C bond formation, arylcarbamoyl chloride, amide