Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3285-3291.DOI: 10.6023/cjoc202012046 Previous Articles     Next Articles



易荣楠a,b, 刘冬娴a, 贺江南a, 赵明明a, 许新华b,*()   

  1. a 湖南警察学院刑事科学技术系 长沙 410138
    b 湖南大学化学化工学院 化学传感与计量学国家重点实验室 长沙 410082
  • 收稿日期:2020-12-28 修回日期:2021-04-18 发布日期:2021-06-02
  • 通讯作者: 许新华
  • 基金资助:
    湖南省科技重大专项(2014FJ1010); 湖南省自然科学基金(2018JJ2019)

Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones

Rongnan Yia,b, Dongxian Liua, Jiangnan Hea, Mingming Zhaoa, Xinhua Xub()   

  1. a Department of Criminal Technology, Hunan Police Academy, Changsha 410138
    b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082
  • Received:2020-12-28 Revised:2021-04-18 Published:2021-06-02
  • Contact: Xinhua Xu
  • Supported by:
    Important Science & Technology Specific Projects in Hunan Province(2014FJ1010); Natural Science Fundation of Hunan Province(2018JJ2019)

A green and efficient method for the synthesis of 3-trifluoromethylquinoxalin-2(1H)-ones via direct trifluoromethylation of quinoxalin-2(1H)-ones with CF3SO2Na promoted by ammonium persulfate ((NH4)2S2O8) under mild conditions has been developed. This process is scalable and tolerates a wide spectrum of quinoxalin-2(1H)-one derivatives to deliver corresponding products in good to excellent yields. Comparing to the previous methods, this strategy has the advantages of wide functional groups tolerance, high yield and simple operation, providing an efficient synthetic approach to 3-trifluoromethyl- quinoxalin-2(1H)-ones.

Key words: ammonium persulfate, trifluoromethylation, quinoxalin-2(1H)-one derivatives, CF3SO2Na