Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (7): 2861-2874.DOI: 10.6023/cjoc202101055 Previous Articles Next Articles
ARTICLES
刘旭, 苏路路, 周昭希, 牛丽萍, 高利刚, 琚欢欢, 李丰兴, 李小六, 陈华*()
收稿日期:
2021-01-30
修回日期:
2021-02-18
发布日期:
2021-03-25
通讯作者:
陈华
基金资助:
Xu Liu, Lulu Su, Zhaoxi Zhou, Liping Niu, Ligang Gao, Huanhuan Ju, Fengxing Li, Xiaoliu Li, Hua Chen()
Received:
2021-01-30
Revised:
2021-02-18
Published:
2021-03-25
Contact:
Hua Chen
Supported by:
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Xu Liu, Lulu Su, Zhaoxi Zhou, Liping Niu, Ligang Gao, Huanhuan Ju, Fengxing Li, Xiaoliu Li, Hua Chen. Design and Synthesis of Benzimidazole-Iminosugars and Their Inhibitory Activities against Glycosidases[J]. Chinese Journal of Organic Chemistry, 2021, 41(7): 2861-2874.
C-5 (六元环) | δ | C-4 (五元环) | δ |
---|---|---|---|
6a-1 | 44.3 | 6a-2 | 59.8 |
6b-1 | 44.5 | 6b-2 | 58.9 |
6c-1 | 44.2 | 6c-2 | 57.9 |
7a-1 | 45.9 | 7a-2 | 61.0 |
7b-1 | 45.9 | 7b-2 | 60.1 |
7c-1 | 45.6 | 7c-2 | 60.0 |
C-5 (六元环) | δ | C-4 (五元环) | δ |
---|---|---|---|
6a-1 | 44.3 | 6a-2 | 59.8 |
6b-1 | 44.5 | 6b-2 | 58.9 |
6c-1 | 44.2 | 6c-2 | 57.9 |
7a-1 | 45.9 | 7a-2 | 61.0 |
7b-1 | 45.9 | 7b-2 | 60.1 |
7c-1 | 45.6 | 7c-2 | 60.0 |
化合物 | 抑制率/% | ||
---|---|---|---|
α-葡萄糖糖苷酶 (黑曲霉) | β-葡萄糖糖苷酶 (杏仁) | α-半乳糖糖苷酶 (咖啡豆) | |
6a-1 | —a | — | — |
6a-2 | — | — | 6.4 |
6b-1 | — | — | — |
6b-2 | — | — | — |
6c-1 | — | — | — |
6c-2 | 1.2 | 1.6 | — |
7a-1 | — | 2.0 | — |
7a-2 | — | — | 8.2 |
7b-1 | — | — | 5.2 |
7b-2 | — | — | 2.1 |
7c-1 | — | 1.4 | — |
7c-2 | — | — | — |
13a | — | — | — |
13b | — | — | 32.6 |
15 | — | 54.5 (10.5b) | 9.8 |
17a | — | 50.4 (11.7) | 12.2 |
17b | — | 3.4 | 8.6 |
17c | — | — | — |
17d | — | — | — |
17e | — | — | — |
19 | — | 24.1 | — |
28a | — | — | — |
28b | — | — | — |
1 | 70.6 (6.4) |
化合物 | 抑制率/% | ||
---|---|---|---|
α-葡萄糖糖苷酶 (黑曲霉) | β-葡萄糖糖苷酶 (杏仁) | α-半乳糖糖苷酶 (咖啡豆) | |
6a-1 | —a | — | — |
6a-2 | — | — | 6.4 |
6b-1 | — | — | — |
6b-2 | — | — | — |
6c-1 | — | — | — |
6c-2 | 1.2 | 1.6 | — |
7a-1 | — | 2.0 | — |
7a-2 | — | — | 8.2 |
7b-1 | — | — | 5.2 |
7b-2 | — | — | 2.1 |
7c-1 | — | 1.4 | — |
7c-2 | — | — | — |
13a | — | — | — |
13b | — | — | 32.6 |
15 | — | 54.5 (10.5b) | 9.8 |
17a | — | 50.4 (11.7) | 12.2 |
17b | — | 3.4 | 8.6 |
17c | — | — | — |
17d | — | — | — |
17e | — | — | — |
19 | — | 24.1 | — |
28a | — | — | — |
28b | — | — | — |
1 | 70.6 (6.4) |
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