Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3753-3770.DOI: 10.6023/cjoc202104004 Previous Articles     Next Articles

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廉价金属(铜、钴、镍)催化的导向碳氢键胺化反应研究进展

冯亚岚, 史炳锋*()   

  1. 浙江大学化学系 杭州 310027
  • 收稿日期:2021-04-01 修回日期:2021-04-15 发布日期:2021-04-16
  • 通讯作者: 史炳锋
  • 基金资助:
    国家自然科学基金(21925109); 国家自然科学基金(21772170)

Recent Advances in Base Metal (Copper, Cobalt and Nickel)-Catalyzed Directed C—H Amination

Ya-Lan Feng, Bing-Feng Shi()   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027
  • Received:2021-04-01 Revised:2021-04-15 Published:2021-04-16
  • Contact: Bing-Feng Shi
  • Supported by:
    National Natural Science Foundation of China(21925109); National Natural Science Foundation of China(21772170)

Nitrogen-containing organic compounds are ubiquitous in natural products, drug molecules and organic intermediates. Therefore, the introduction of nitrogenous functional groups into organic compounds is of great significance. Despite transition metal-catalyzed C—N coupling reaction provided an effcient strategy to access these ntrogen-containing compounds, extra steps are generally required to obtain the pre-functionalized starting materials. Recently, transition metal-catalyzed C—H amination has emerged as a more atom- and step-economical strategy to construct C—N bonds. Compared to the noble metals (e.g. palladium and rhodium), base metal catalysts, such as copper, cobalt and nickel, have attracted dramatic attentions, due to their earth abundance, cost effectiveness, and unique catalytic activities. Herein, the recent advances in copper-, cobalt- and nickel-catalyzed C—H amination reactions assisted by directing groups were summmarized according to the types of base metals, C—H bonds, and amination reagents with an emphasis on the discussion of various amination reagents and their application. Finally, the limitations and development trend of this research field are analyzed and prospected.

Key words: base metal, C—H activation, amination, directing group, copper, cobalt, nickel