Progress in the Synthesis of Aroyl Compounds

doi:10.6023/cjoc202104049

Abstract

Aroyl compounds exhibit various biological activities and are important fine chemicals as well. Therefore, their synthetic methods have attracted considerable attention. It is the first time to summarize the synthetic methods of aroyl compounds in the past five to eight years. These reactions can be classified into three parts by their reaction mechanism, namely, coupling reaction catalyzed transition metals, the free radical mechanism and aromylation reactions carried out by other mechanisms. It is expected that inspiration of new synthetic methods will be provided for the synthesis of compounds bear aroyl group in this review.

Key words: aroyl group, reaction mechanism, synthetic method

Cite this article

Liang Liu, Wenbo Liu, Dong-Mei Cui, Ming Zeng. Progress in the Synthesis of Aroyl Compounds[J]. Chinese Journal of Organic Chemistry, 2021, 41(11): 4289-4305.

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Fig. & Tab. 23

Scheme 1. Possible reaction mechanism for the synthesis of 3-Aroyl indole

Scheme 2. Possible reaction mechanism

Scheme 3. Possible reaction mechanism for the synthesis of diaryl ketone

Scheme 4. Possible reaction mechanism for the synthesis of dimethylaminopyridinium salts

Scheme 5. Possible reaction mechanism for the synthesis of arylamide

Scheme 6. Possible reaction mechanism for synthesis of aroyl pyrrolidone

Scheme 7. Possible reaction mechanism for the synthesis of 3- aroylpyridopyrroles

Scheme 8. Possible reaction mechanism for the synthesis of 2-aroyl benzofurans

Scheme 9. Possible reaction mechanism of the aromatic acylation of 2-arylpyridine

Scheme 10. Possible reaction mechanism for rhodium catalyzed synthesis of aryl formaldehyde

Scheme 11. Possible mechanism for copper catalyzed synthesis of 2-aroyl substituted triazinoimidazoles

Scheme 12. Possible reaction mechanism for palladium catalyzed aromatic acylation of 2-arylpyridine

Scheme 13. Possible reaction mechanism for palladium catalyzed synthesis of 2-aroyl substituted benzothiazole derivatives

Scheme 14. Possible mechanism for photocatalytic aromatic acylation of α,β-unsaturated ketones

Scheme 15. Possible reaction mechanism for photocatalytic aromatic acylation of α,β-unsaturated ketones with aroyl chloride

Scheme 16. Possible reaction mechanism for photocatalytic aromatic acylation of alkenes with aroyl chloride

Scheme 17. Possible reaction mechanism for photocatalytic aroyl fluoride as acylation reagent

Scheme 18. Possible mechanism for the photocatalytic synthesis of benzopyrrolone

Scheme 19. Possible mechanism for photocatalysis promotes the arylformylation of amines

Scheme 20. Aryl keto acid as aroformylation reagent under visible light catalysis

Scheme 21. Possible mechanism for aromatic acylation of coumarin

Scheme 22. Possible mechanism for the synthesis of 2-aroyl benzofuran via [2+2] coupling and [4+1] cyclization

Scheme 23. Possible reaction mechanism for synthesis of aroyl compounds by methylene oxidation

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